Advancing Parkinson's Disease Understanding in Central Asia

 

The Genomic Parkinson's Disease Project (GP2) is committed to deepening our comprehension of Parkinson's disease (PD) by genotyping diverse participant groups and exploring highly suspected monogenic forms of PD. Through global collaboration, transparent data sharing, and open processes, we're amassing diverse cohorts worldwide to achieve our mission.

Our endeavor is to examine whether the clinical course and presentation of PD in Central Asia (CAT) exhibit distinct characteristics compared to the global norm. Our hypothesis is that studying PD genetics in the CAT region could unveil novel candidate genes and risk variants, potentially shaping future PD research. Our objective is to establish trial-ready cohorts for future investigations.

Key Aims of the Project:

• Characterizing PD in CAT:

• Investigate the clinical presentation and progression of 1250 PD patients and matched spouse controls in CAT.

• Define unique risk factors associated with PD in CAT.

• Compare PD characteristics between CAT and Western and Eastern populations.

• Exploring Genetic Background:

• Uncover the genetic underpinnings of PD in CAT by collaborating with GP2.

• Compare the CAT genetic landscape with global datasets.

• Pave the way for large-scale, multicenter PD studies in CAT.

• Creating a Valuable Biobank:

• Establish a comprehensive biobank containing DNA, plasma, urine, and feces biomarkers extracted from CAT-PD and spouse populations.

• Facilitate future research by sharing this biobank with the scientific community.

• Enabling Trial-Readiness:

• Assemble cohorts ready for clinical trials from CAT-PD populations.

• Lay the foundation for innovative research to evaluate potential treatments and interventions.

Collaborative Effort: This ambitious study will be carried out by a team of movement disorders experts hailing from the CAT region. They will be under the guidance of Principal Investigators (PI) and Co-PIs from the University College London (UCL). This collaboration brings together diverse expertise to tackle PD from multiple angles and perspectives, ensuring comprehensive insights into the disease's dynamics within the CAT region.

By investigating PD intricacies in CAT, we aspire to make substantial contributions to the global understanding of this complex neurological disorder. This effort not only holds promise for uncovering novel insights but also exemplifies the power of international collaboration in pushing the boundaries of medical research. Through sharing knowledge, resources, and a common goal, we aim to pave the way for improved diagnostics, treatments, and ultimately, a better quality of life for those affected by Parkinson's disease.